A late night television talk show hosted by Conan O'Brien.

After the great disaster of 2008, a war that destroyed the planet, the world is now largely ocean with the continents having sunk. Conan lives on a remote island with his grandpa and nature, never having seen another human being. But one day a mysterious girl, Lana, washes up on his beach. The two become quick friends, but she’s soon kidnapped and taken to Industria, a technological remainder from the world before. Conan leaves his island in pursuit, braving new lands and many hardships with new friends and enemies just beyond the horizon.

A quest that begins as a personal vendetta for the fierce Cimmerian warrior soon turns into an epic battle against hulking rivals, horrific monsters, and impossible odds, as Conan realizes he is the only hope of saving the great nations of Hyboria from an encroaching reign of supernatural evil.

Stepping into the late-late slot vacated by David Letterman, Conan O'Brien stars in a show that far outdoes its competition in sheer strangeness. Along with the celebrity interviews and musical numbers typical of late-night talk shows, this program make frequent use of odd walk-on characters and frequent "visits" from celebrity guests.

At the opening ceremony of the WSG (World Sports Games) Tokyo Games, a sports festival held once every four years, it is announced that the world's first vacuum superconducting maglev with a maximum speed of 1,000 kilometers per hour will open. While attracting attention from around the world, top executives of large companies are kidnapped from the party venue where WSG tournament sponsors gather. Conan moves toward a solution and eventually finds a connection with the WSG abduction case that occurred 15 years ago in Boston, USA.

After 25 years at the Late Night desk, Conan realized that the only people at his holiday party are the men and women who work for him. 　　Over the years and despite thousands of interviews, Conan has never made a real and lasting friendship with any of his celebrity guests. So, he started a podcast to do just that. 　　Deeper, unboundedly playful, and free from FCC regulations, Conan O’Brien Needs a Friend is a weekly opportunity for Conan to hang out with the people he enjoys most and perhaps find some real friendship along the way.

As police inspector Yamato Kansuke pursues a certain man in the snowy mountains of Nagano, a shadow suddenly appears in his field of vision. While he's distracted, a rifle bullet fired by someone grazes his left eye and causes an avalanche accompanied by a roar. Ten months later, Kansuke, having miraculously survived the avalanche, receives a report that a researcher at the Nobeyama National Astronomical Observatory has been attacked.

Shibuya, Tokyo, is bustling with the Halloween season. A wedding is being held at Shibuya Hikarie, where Detective Miwako Sato of the Metropolitan Police Department is dressed in a wedding dress. While Conan and the other invited guests are watching, an assailant suddenly bursts in, and Detective Wataru Takagi, who was trying to protect Sato, is injured. Takagi survived and the situation was settled, but in Sato's eyes, the image of the grim reaper that she had seen when Detective Matsuda, the man she had been in love with, had been killed in a series of bombings three years ago, overlapped with Takagi's.